Autism And Why It Impacts Everyone

This is a short overview of autism science and biology designed for people in the general public who have no experience with autism.  The talk reviews many initial false assumptions about autism and where the science is now pointing. We will review genetic risk factors, with emphasis on the primary genetic risk factor: calcium channel signaling.  Environmental and biological factors that impact that pathway will be discussed, which is critical to autism, but also impacts everyone.

Slides: Autism and Why It Impacts Everyone

References

CDC increases estimate of autism’s prevalence by 15 percent, to 1 in 59 children

CDC Says Developmental Disabilities Are On The Rise

The Root Cause in the dramatic rise of Chronic Disease

The infertility crisis is beyond doubt. Now scientists must find the cause

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Hallmayer, Joachim, et al. "Genetic heritability and shared environmental factors among twin pairs with autism." Archives of general psychiatry 68.11 (2011): 1095-1102.

Regressive Autism

The Kids Who Beat Autism

Ng, Michelle, et al. "Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013." Chronic Diseases and Injuries in Canada 37.1 (2017).

Rossignol, D. A., S. J. Genuis, and R. E. Frye. "Environmental toxicants and autism spectrum disorders: a systematic review." Translational psychiatry 4.2 (2014): e360.

The Environmental and Genetic Causes of Autism (2016) by James Lyons-Weiler

Faber, Scott, et al. "A clean room sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders." BMC complementary and alternative medicine 15.1 (2015): 71.

Neurotribes: One Step Forward, Two Steps Back for Autism

NIH: Autism Spectrum Disorder: Genetics

[9] Wen, Ya, Mohamad J. Alshikho, and Martha R. Herbert. “Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling.” Plus one 11.4 (2016): e0153329.

De Novo Mutations - account for 50% of autism cases

Martin Pall “EMFs and Chemicals as the Two Main Drivers of the Autism Epidemic: Mechanisms of Action

Wu, Jianping, et al. "Structure of the voltage-gated calcium channel Cav1. 1 complex." Science 350.6267 (2015): aad2395.

Büsselberg, Dietrich. "Calcium channels as target sites of heavy metals."Toxicology letters 82 (1995): 255-261.

Lozac, N. B. S. "Central role of voltage gated calcium channels and intercellular calcium homeostasis in autism." (2010)

Feske, Stefan. "Ca2+ influx in T cells: How many Ca2+ channels?." Frontiers in immunology 4 (2013): 99.

Naviaux, Robert K. "Metabolic features of the cell danger response." Mitochondrion 16 (2014): 7-17.

The Environmental and Genetic Causes of Autism (2016) by James Lyons-Weiler

Ng, Michelle, et al. "Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013." Chronic Diseases and Injuries in Canada 37.1 (2017).

Rossignol, D. A., S. J. Genuis, and R. E. Frye. "Environmental toxicants and autism spectrum disorders: a systematic review." Translational psychiatry 4.2 (2014): e360.

Landrigan, Philip J., Luca Lambertini, and Linda S. Birnbaum. "A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities." (2001).

Raz, Raanan, et al. "Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case–control analysis within the Nurses’ Health Study II cohort." (2014).

Calderón-Garcidueñas, Lilian, et al. "Air pollution and detrimental effects on children’s brain. The need for a multidisciplinary approach to the issue complexity and challenges." Frontiers in human neuroscience 8 (2014).

Cavalli, Vera Lúcia de Liz Oliveira, et al. "Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells." Free Radical Biology and Medicine 65 (2013): 335-346.

Fluegge, Keith. "Autism in 2016: additional discovery." Jornal de Pediatria (2016).

Faber, Scott, et al. "A cleanroom sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders." BMC complementary and alternative medicine 15.1 (2015): 1.

Adams, James B., et al. "Mercury, lead, and zinc in baby teeth of children with autism versus controls." Journal of Toxicology and Environmental Health, Part A 70.12 (2007): 1046-1051.

Geier, David A., Janet K. Kern, and Mark R. Geier. "A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity." Acta Neurobiol Exp (Wars) 69.2 (2009): 189-97.

Mohamed, Farida El Baz, et al. "Assessment of hair aluminum, lead, and mercury in a sample of autistic Egyptian children: environmental risk factors of heavy metals in autism." Behavioural neurology 2015 (2015).

Carrascosa-Romero, Maria Carmen, and Carlos De Cabo-De La Vega. "The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications." Autism-Paradigms, Recent Research and Clinical Applications. InTech, 2017.

Karimi, Padideh, et al. "Environmental factors influencing the risk of autism." Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences 22 (2017).

Modabbernia, Amirhossein, Eva Velthorst, and Abraham Reichenberg. "Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses." Molecular Autism 8.1 (2017): 13.

Ng, Michelle, et al. "Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013." Chronic Diseases and Injuries in Canada 37.1 (2017).

Mark Zylka, “Exploiting genetics to identify environmental risks for autism

Rossignol, D. A., S. J. Genuis, and R. E. Frye. "Environmental toxicants and autism spectrum disorders: a systematic review." Translational psychiatry 4.2 (2014): e360.

Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int 24-Mar-2015;6:45

Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link–Part I." Pathophysiology 20.3 (2013): 191-209.

Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link Part II." Pathophysiology 20.3 (2013): 211-234.

Pall, M.L., Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression, Journal of Chemical Neuroanatomy (2015).

Pall, M.L., The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs: Downstream Effects Cause Autism (Conference Presentation). 2015.

Pall, Martin L. "Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects." Journal of cellular and molecular medicine 17.8 (2013): 958-965.

Waldman, Michael, Sean Nicholson, and Nodir Adilov. Does Television Cause Autism?. No. w12632. National Bureau of Economic Research, 2006.

Victoria L. Dunckley MD  “Reset Your Child's Brain: A Four-Week Plan to End Meltdowns, Raise Grades, and Boost Social Skills by Reversing the Effects of Electronic Screen” (2015)

Jia, Feiyong, et al. "Core symptoms of autism improved after vitamin D supplementation." Pediatrics 135.1 (2015): e196-e198.

Corbett, Blythe A., et al. "Cortisol circadian rhythms and response to stress in children with autism." Psychoneuroendocrinology 31.1 (2006): 59-68.

Bauer, Ann Z., and David Kriebel. "Prenatal and perinatal analgesic exposure and autism: an ecological link." Environ Health 12.1 (2013): 41.

Jane Webb, Sara, et al. "Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound." Autism Research (2016).

To: California Representatives Voting on SB 649

California SB 649 is a litmus test for industry influence. Are you going to serve California, its cities, and your constitutions, or are you going to be manipulated by AT&T and other telecom companies?

If you are inclined to vote yes, I want to make sure you are fully aware of several key factors:

The California Department of Health wrote cell phone safety guidelines for the public in 2010, but those guidelines were suppressed for 7 years until a lawsuit forced their release this year. Have you asked the California Department of Health or Cal EPA about the public health and environmental impacts of SB 649?

The largest class action lawsuit in the history of the United States is scheduled to start trial this fall in Washington D.C. The lawsuit is a collection of claims about cell phones and brain cancer. A recent similar trial in Italy found sufficient scientific evidence of harm and ruled against the wireless industry.

The final results of the National Institutes of Health’s 25 million dollar study on 2G cellular technology will be released in early 2018. The partial results, pre-released in May 2016, already demonstrated that 2G technology damages DNA and fails safety testing. Does 5G technology cause more or less DNA damage? Is it legal to roll out the network without safety testing and without disclosure and consent?

The weight of the scientific evidence shows wireless exposure causes sperm damage, including DNA damage. Scientists have found that 50% of autism cases have non-inherited mutations, mostly from the father’s side (sperm damage).  

In 2011, the World Health Organization listed radio frequency radiation (wireless) as a group 2B carcinogen (possible carcinogen). Researchers believe we now have sufficient evidence to move that categorization to group 1 (known carcinogen), the same level as smoking.  How would your yes vote be viewed when this happens? What are the ramifications for California’s Proposition 65?

The documentary film Generation Zapped will be released this fall. Just watching the 2-minute trailer is enough to create grave doubts about the safety of wireless in the majority of people who view it.

Have proponents of SB 649 made any disclosure of the health and safety implications of the bill? If not, how can you trust them?

Thank you for serving the people of California.

Peter Sullivan
Los Altos, California